Author Amy Rothberg is part of the Investigational Weight Management Clinic, a clinical-research team that’s conducting a large Weight Management study to examine how best to help those who are obese reduce their weight and keep it off in an effort to minimize their risk of developing diabetes.
When it comes to diabetes clinical research, the majority of studies are related to exploring new drug treatments. The Weight Management study differs in that it’s also focused on the impact that lifestyle changes have on those who are obese, particularly in the effort to prevent them from developing diabetes. In addition to lifestyle changes, we do look at options that, in some cases, include bariatric surgery and medications. We understand that weight loss is not one-size-fits-all, and each person’s journey is unique.
Since 2010, we have enrolled more than 500 people in our study and have seen an almost 65% remission rate in Type 2 diabetes. We have found that even a modest weight loss has been shown to delay the progression to diabetes, confirming earlier intervention trial results such as those from the Diabetes Prevention Program. Most participants have been able to reduce their weight and have improved diabetes control, but they also have a marked reduction in all of their medications, and they have much greater improvement in health-related quality of life.
We know that people need structure to lose weight, but they often don’t have the tools. Our program is the tool kit to get it done. People get phenomenally excited by the results they see in our clinic. We hear “Why did I wait so long?” all the time. They are even more motivated to keep going once they lose weight, reduce or eliminate medications, and move better for longer periods of time.
To expand on the study’s early findings, we’re continuing to enroll volunteers for our two-year clinical research program. If you or someone you love has a Body Mass Index (BMI) of 35 or greater, you may be eligible. Learn more about how you may be able to take part in this study.
Make a difference for yourself and others
Volunteers are very important to the work we do—we can’t make progress in diabetes prevention and treatment without them. They are the most critical part of clinical research. People become more invested in their own health when they participate, even when it is more time-consuming. We recognize the efforts, time and commitment that they invest to help us, and we’re eternally grateful for that. To solve these problems and to fix these issues, we need volunteers. Not just people who are sick, but also healthy people from whom we can also learn.
My biggest goal is to put a notch in lowering the epidemic of obesity and diabetes. Finding out what factors contribute to maintaining weight loss in order to maintain the maximum health benefits, whether through drugs, lifestyle intervention, surgery or a combination of any or all of these, will go a long way to ending obesity and type 2 diabetes.
Take the next step:
- Learn more about the Investigational Weight Management Clinic.
- Find out more about how patients and healthy volunteers can help diabetes clinical research at U-M.
- Learn more about the U-M Comprehensive Diabetes Center.
Amy E. Rothberg, M.D., is Assistant Professor of Internal Medicine in the Division of Metabolism, Endocrinology and Diabetes (MEND), and Director of the MEND Investigational Weight Management Clinic.
The University of Michigan Comprehensive Diabetes Center is committed to preventing, treating, and curing all forms of diabetes through patient care and advanced research.