In recognition of brain cancer awareness month, the focus of my blog is on the latest developments in treating this particular cancer. Glioblastoma or glioblastoma multiforme is the most common brain cancer in adults. According to the American Brain Tumor Association, glioblastomas represents about 17% of all primary brain tumors. They can be difficult to treat because the tumors contain so many different types of cells. They tend to be both aggressive and fast growing. The National Cancer Institute says the mortality rate for brain cancer has remained largely unchanged over the past 30 to 40 years. Therefore looking at new ways to treat brain cancer is desperately needed.
One of the hottest areas of clinical research into brain cancer involves the use of immunotherapy, or stimulating the immune system to attack cancer. The National Cancer Institute defines Continue reading →
Are certain drugs more effective against some types of prostate cancers than others? Researchers know that not all therapies work for all patients – the next question is to figure out how to match the right treatments with the right patients.
A new clinical trial is testing whether an experimental drug can maximize the effect of current treatment and whether matching that drug to a genetic anomaly can lead to better, more personalized treatment for prostate cancer. The trial, led by investigators at the University of Michigan Comprehensive Cancer Center, is being conducted at 11 sites throughout the country. Continue reading →
If you are a breast cancer survivor, caregiver or member of the general public concerned about breast cancer, please join us for a Breast Cancer Summit on Saturday, April 20, at Washtenaw Community College. The summit bridges the gap between our community and academic medicine by giving the audience a chance to ask questions and interact with U-M breast cancer specialists. Many are leaders nationally in the fight against breast cancer.
Maria Lyzen, right, and Ruth Freedman lead the Cancer Center’s Breast Cancer Advisory and Advocacy Committee.
The summit was organized through encouragement from the U-M Comprehensive Cancer Center’s breast cancer advocates. They feel the summit is a way to let the community know that the U-M breast cancer specialists are collaborative and multidisciplinary. Panel discussions and a mock tumor board will give the audience a first-hand look at how these leading oncologists work together on behalf of their patients. They will also give an update on the latest breast cancer research at Michigan and nationally, showing what has been learned and how vital research donations are to these research advances.
“Your doctor said you need WHAT?” People can feel a bit uneasy when a doctor mentions screening for colon cancer or rectal cancer.
Danielle Turgeon, M.D., is one of the University of Michigan gastroenterologists who perform colonoscopies.
But, according to the American Cancer Society, colorectal cancer is the third most common cancer in both men and women in the United States. Preventing colorectal cancer, and not just finding it early, is why doctors recommend colorectal screening tests, even though the subject may seem embarrassing to discuss.
Colorectal cancer starts in the colon or rectum, most often as a polyp, or small piece of tissue that projects from the inner wall. Screening tools can find cancer in people before symptoms show up, which is when colorectal cancer is most easily treatable. Some also can find and remove suspicious-looking polyps before they become cancerous, which may prevent colorectal cancer.
Who should be screened:
Starting at age 50, men and women of average risk for colorectal cancer
People with a personal or family history of colorectal cancer or pre-cancerous polyps
People with inflammatory bowel disease
People with certain other risk factors, including a known family history of a hereditary colorectal cancer syndrome
Many types of tumors can start in the thyroid gland, which is in the front of the neck, below the Adam’s apple. Most of them are benign (non-cancerous) but others are malignant (cancerous), which means they can spread into nearby tissues and to other parts of the body. The two most common types of cancer are papillary carcinoma and follicular carcinoma. There are other types of thyroid cancer, which are rare.
Thyroid cancer is commonly diagnosed at a younger age than most other adult cancers. Nearly two out of three cases are found in people younger than 55 years of age. About 2% of thyroid cancers occur in children and teens.
Ronald J. Koenig, M.D.
Most thyroid cancers can be cured by surgery and radioactive iodine. However, thyroid cancers not cured by those therapies present a problem. As a rule, thyroid cancers do not respond well to chemo. But unlike standard chemo drugs, targeted drugs attack certain targets on cancer cells. The targets they attack can be present on normal cells as well, but the goal is to find targets that help cancer cells grow and thrive.
Ronald Koenig, M.D., Ph.D., professor of internal medicine at U-M, heads a research team focused on developing targeted drug therapies for thyroid cancer. He talked with mCancer Partner about a new clinical trial that is opening enrollment for certain patients with thyroid cancer.
mCancer Partner: Can you tell me about your newest clinical trial?
Dr. Koenig: In this new trial, to be funded by the National Cancer Institute, we are investigating whether a drug, Actos (pioglitazone), is useful in treating a certain kind of thyroid cancer. Actos is approved by the FDA to treat diabetes, but has not been approved yet to treat any cancers.
mCancer Partner: Who can enroll in this clinical trial?
Dr. Koenig: We will enroll adults with a history of follicular thyroid carcinoma or follicular variant of papillary thyroid carcinoma. These people must have metastatic disease or disease that has recurred locally in the neck, and that cannot be cured by further surgery or radioiodine. We will treat them for at least 24 weeks with daily pioglitazone and measure for response using CT scans and blood tests.
mCancer Partner: Where can someone learn more about this clinical trial?
Dr. Koenig: Details, along with contact information for enrolling, are available through UMClinicalStudies. This is a helpful website allowing people to easily search and find clinical and health research studies happening at the U-M. Our study’s ClinicalTrials.gov Identifier is NCT01655719.
Learn more about the Cancer Center’s thyroid cancer program or call the U-M Cancer AnswerLine at 800-865-1125 to speak with a nurse.
The pancreas is located deep inside the body, so early tumors cannot be seen or felt by health care providers during routine physical exams. This makes it hard to see the pancreas with imaging technologies and sometimes makes it difficult to access to remove cells for a biopsy.
Pancreatic cancer is a relatively rare cancer and it typically affects people older than age 50. Pancreatic cancer is hard to diagnose because the early symptoms are usually vague. Early symptoms may be nothing more than a general feeling of discomfort in the abdomen or an unexplained weight loss.
Another factor that makes pancreatic cancer so deadly is its resistance to treatment. At this time, the only possibility for long-term survival is surgically removing the cancer. Researchers are working on ways to detect the disease earlier, because that might allow more people to be eligible for surgery.
Blood tests- Elevated blood levels of the tumor markers CA 19-9 and carcinoembryonic antigen (CEA) may point to a diagnosis of pancreatic cancer made of exocrine cells, but these tests aren’t always accurate
Biopsy – A patient’s history, physical exam, and imaging test results may strongly suggest pancreatic cancer, but the only way to be sure is to remove a small sample of tumor and look at it under the microscope. This procedure is called a biopsy.
When disease has advanced beyond surgery’s reach, chemotherapy is the standard treatment. Two drugs are FDA-approved for the treatment of pancreatic cancer: gemcitabine (Gemzar) and erlotinib (Tarceva).
Research focusing on pancreatic cancer is increasing. Researchers are investigating ways to more effectively screen for the disease and examining possibilities for better treatment options.
U-M is involved in pancreatic cancer research; if you would like to learn more about our research and clinical trials, the following resources are available: