Children and young adults who have inflammatory bowel disease (IBD) like Crohn’s disease, indeterminate colitis, or ulcerative colitis require careful and diligent medical management to minimize and prevent flare-ups of symptoms, complications, surgeries, and days spent in the hospital.
IBD is a challenging disease to have because right now there is no cure, and symptoms tend to wax and wane over time. For children especially, this can mean they look “normal” on the surface to their peers, but they may be struggling off and on with abdominal pain, vomiting, diarrhea, and fatigue that prevent them from participating in the activities they would like to pursue. As a result, IBD can be uncomfortable, discouraging, and socially isolating.
Helping end a symptomatic flare of IBD and stay in remission can be a process of trial and error, but it is important to get right so children with IBD can live normal and healthy lives. We believe there is always room for improvement, and there’s so much more we want to know about how we can help manage pediatric IBD more effectively.
Antibiotic-induced shifts in bacterial makeup allow C. difficile to grow.
One of the most common antibiotic-related illnesses, Clostridium difficile, also known as “C. diff,” poses a threat to thousands of Americans hospitalized each year. While most hospital-acquired infections are declining, C. diff is on the rise and causes diarrhea linked to 14,000 American deaths each year.
Major risk factors for getting this infection include staying in the hospital and taking antibiotics.
A new study by the University of Michigan Medical School reveals how antibiotics not only change the bacterial makeup of the gut but also foster the availability of metabolites, which C. difficile can use for germination and growth.
“The findings in our paper are not only vital to the development of new-targeted therapeutics for combatting C. difficile infection but could aid in understanding other gut inflammatory and metabolic diseases, including diabetes, obesity and inflammatory bowel disease, where changes in the gut microbiome could be intimately related to the chemical and nutrient environment,” says lead author Casey Theriot, Ph.D., Research Investigator in the Division of Infectious Diseases at the University of Michigan Medical School.
NOTICE: Except where otherwise noted, all articles are published under a Creative Commons Attribution 3.0 license. You are free to copy, distribute, adapt, transmit, or make commercial use of this work as long as you attribute the University of Michigan Health System as the original creator and include a link to this article.