A Spanish research team has recently found that giving uric acid (UA) with intravenous thrombolytic therapy (tPA) to patients with acute ischemic stroke could help improve outcomes, particularly in women. Emergency Medicine Physician Dr. William J. Meurer talked with us about the study and its implications for stroke treatment and research.
Do the results of the Spanish study mean that hospitals will start supplementing clot-busting tPA with uric acid (UA) when they treat ischemic stroke patients?
No. The main trial didn’t find UA to work when given to everyone. The Spanish researchers have generated an interesting hypothesis by observing that it worked in women. There is not strong enough evidence yet to change practice, but it’s an interesting area for future research.
How did the team conduct the research?
The researchers reexamined the results of their Efficacy Study of Combined Treatment with Uric Acid and rtPA in Acute Ischemia Stroke (URICO-ICTUS) trial. Continue reading