Studies in mice indicate that our brains may go through a process while we sleep that rids them of toxins that build up during the day
Did you ever wonder what happens to our brains at night? If recent studies in mice are any indication, our brains may go through a process that rids them of toxins that build up during the day.
The studies suggest that during sleep, there is an expansion of extracellular space within the brain that corresponds with increased fluid movement around and into the deep parts of the brain. This fluid movement is associated with a more robust exchange of small compounds into and out of the brain itself.
In mice studies, some of these compounds include toxic proteins—namely amyloid beta protein, which is implicated in the development of Alzheimer’s disease and other dementias. How external fluid moves into, within and out of the brain tissue still remains a mystery. Continue reading →
On the Friday our son Dominic turned 9 weeks old, he started throwing up immediately after eating. This continued on and off through out the weekend, so we took him to the pediatrician first-thing Monday. During that appointment, the doctor noticed that his head circumference seemed to be not following the normal growth curve. He sent us to a nearby hospital right away.
There they did an ultrasound and MRI, which revealed that Dominic had a brain tumor. On July 23, 2014, he underwent a seven hour tumor resection. The tumor was quite large, about 40 percent of his brain space. One week later, we learned the tumor was a rare, cancerous tumor, called a Choroid Plexus Carcinoma. We knew the road ahead of us would be a long one. Unfortunately, we just didn’t feel like the hospital we were at was a good fit for us, so we transferred Dominic’s care to C.S. Mott Children’s Hospital.
When Anna Dai and Efrain Segarra signed up to take an entry-level computer engineering course at University of Michigan, they expected to learn about game software development.
What they did not expect was to find themselves taking gaming to a whole new level through a massive project at U-M C.S. Mott Children’s Hospital. Thanks to their efforts – along with the generosity of dozens of other individuals and groups – patients at Mott will now find their room equipped with an Xbox 360.
Out of the classroom, into the real world
Efrain Segarra was a freshman when he took Professor David Chesney’s course.
“Dr. Chesney calls it Gaming for the Greater Good,” says Segarra, referring to the course’s focus on developing software that can benefit children with disabilities.
David L. Brown, MD, addresses the attendees and introduces A. Lee Dellon’s lecture, “Peripheral nerve surgery in 2015.”
After an accident, Sonya Persia went through several back, hip and neck surgeries, but new pain in her legs and feet never went away. Once Sonya and her husband Ray realized there are options beyond pain medication to improve her quality of life, they wanted to help others dealing with the same thing.
“Nobody knew what to do,” Ray Persia said, but they finally read an article about a procedure that fixes chronic pain caused by injury and/or compression of nerves.
The Persias traveled out of state for the surgeries, and now the couple from Highland, Mich., are advocates and donors, helping to bring the option of peripheral nerve surgery to patients at the U-M Health System.
Visualizing new potential targets in ACC. This fluorescence microscopy image shows expression of ZNRF3 (green) in the normal mouse adrenal gland. Collaborative research efforts, including The Cancer Genome Atlas project, have recently mapped the genetic landscape of human ACC tumors and identified ZNRF3 as one of the most commonly altered genes in ACC. Image courtesy of Kaitlin Basham, Ph.D., Postdoctoral Fellow (Hammer Laboratory) and Heather Rose Kornick Adrenocortical Cancer Research Scholar
mCancerPartner sat down with Gary Hammer, M.D., Ph.D., director of the Endocrine Oncology Program in the Comprehensive Cancer Center, to discuss the program’s most recent developments in adrenal cancer research and patient care.
mCancerPartner: Why is collaboration so important in treating adrenal cancer?
Dr. Hammer: Adrenal cancer, or ACC, is very rare, with less than a thousand people diagnosed with it each year in the United States. In adults, it is most often diagnosed at an advanced stage, so for many, the prognosis is dismal. Collaboration is essential because no one hospital sees enough of these patients to advance research or clinical care. Continue reading →
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