The PALB2 gene, which is also called the partner and localizer of BRCA2, is a gene that contributes to inherited susceptibility to breast cancer and perhaps ovarian and pancreatic cancers. The PALB2 gene contains the directions for making a protein that acts together with the BRCA2 protein. When they are functioning normally, these two genes work together as tumor suppressors.
How does cancer start at the genetic level?
Most cancers occur when two mutations in a tumor suppressor gene occur in a single cell during a person’s lifetime. Some individuals inherit an altered copy of a tumor suppressor gene. If a second mutation occurs in the tumor suppressor gene in any cell of their body, a tumor may develop. Since they already have an altered tumor suppressor gene in all of the cells of their body, individuals with an inherited mutation in a tumor suppressor gene are more likely to develop cancer.
Cancer due to an inherited alteration in a tumor suppressor gene is more likely to occur at a younger age (for example, Continue reading →
The Sylvest family tree includes Lynch syndrome, a genetic disorder that can cause cancer.
Lisa Sylvest is a cancer survivor who never met her father Karl’s parents. They lived in Denmark with their other son and daughter. Growing up, Lisa simply knew that her grandmother died at age 54 of a ‘female’ cancer. When Lisa was in high school, Karl’s brother died of brain cancer, also at age 54. Time passed, Lisa entered nursing school and her father’s sister developed endometrial cancer. Lisa traveled to Denmark to meet her relatives face-to-face for the first time.
When her father was diagnosed with advanced colon cancer at age 68, Lisa was a U-M Health System nurse working in gastroenterology, which deals with stomach and intestinal disorders. Her Continue reading →
One of the most recommended screenings is for cervical cancer. Most cervical cancers are caused by the sexually transmitted infection human papillomavirus (HPV). HPV immunization could reduce the impact of cervical cancer worldwide by as much as two-thirds, if all adolescent and adult women were to get the vaccine. According to the Centers for Disease Control and Prevention in Atlanta (CDC), there is no evidence to suggest that HPV vaccine loses the ability to provide protection over time.
Currently there are two vaccines approved by the U.S. Food and Drug Administration, or FDA, that prevent infection from HPV, the most common cause of cervical cancer. Gardasil and Cervarix both are highly effective in preventing infection with the types of HPV they target. Gardasil targets the two HPV types that cause 90% of genital warts and it is used to prevent cancers and precancers of the cervix, vulva, vagina, and anus. Cervarix is used for the prevention of cervical cancer and precancers.
The CDC recommends that all women age 26 years and younger receive three doses of the HPV vaccine (Cervarix or Continue reading →
There is no question that breast cancer disproportionately affects women – but we shouldn’t be so quick to dismiss the risk to men. As we continue to learn more about the ways our genes influence our cancer risk, involvement of male relatives in genetic counseling and genetic testing can provide important information for your family’s breast cancer risk evaluation. So why are men often forgotten?
Myth One: Men don’t carry mutations in breast cancer genes.
Someone called the Cancer AnswerLine™ recently with questions about uterine sarcoma and I spend some time talking with her. This is a fairly rare condition which comprises only 2%-5% of all uterine cancers. Since July is Sarcoma Awareness Month, what better time than now to share these notes?
What is uterine sarcoma?
Sarcoma is a term used to describe a whole family of cancers that arise in the body’s connective tissues, which include, fat, muscle, blood vessels, deep skin tissues, Continue reading →
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