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Hope for advanced heart failure patients

Studies aim to improve quality of life

hope blog

Tremendous advancements have been made since the first U.S. human heart transplant was performed in 1968. Today, promising new studies involving devices and procedures are giving hope to the 5.1 million advanced heart failure patients living in the U.S.

Several studies currently being conducted by physicians, researchers and scientists at the University of Michigan Frankel Cardiovascular Center are building on the success of our Heart Failure Program. These include:

  • MOMENTUM III: This study compares the HeartMate III heart pump with an older version (HeartMate II) to evaluate whether a smaller pump design with new features will benefit patients with advanced stages of heart failure. The heart pump is intended as a bridge to heart transplantation or as destination therapy.
  • CTSN Cell Therapy LVAD Trial II: This study will evaluate the use of stems cells that are injected into the patient’s heart at the time of receiving a Left Ventricle Assist Device (LVAD). This study will determine if stem cells improve the function of the heart.

“This is a significant trial that could give us important insights into the potential for stem cells to improve heart function in patients with advanced heart failure,” says Frankel CVC cardiac surgeon Dr. Francis Pagani.

Another study — EXPAND (Portable Organ Care System – OCS™) — is evaluating a new portable organ care system that perfuses the heart with oxygen and nutrients and keeps a donor heart functioning at normal body temperature while it is transported to a recipient. The trial is testing whether this method of maintaining the donor organ is superior to the current method of storing the heart on ice.

“The EXPAND trial is probably the most important trial we have ongoing now. It might transform the way we do heart transplantation in this country,” says Dr. Pagani.

Take the next step:


Frankel-informal-vertical-sigThe University of Michigan Samuel and Jean Frankel Cardiovascular Center is a top-ranked heart and heart surgery program among Michigan hospitals. To learn more, visit our website at umcvc.org.