Out of sync with the world: Brain study shows body clock is “broken” in depression

The internal circadian rhythm "clock", based in the brain, rules many body functions

The internal circadian rhythm “clock”, based in the brain, rules many body functions

Every cell in our bodies runs on a 24-hour clock, tuned to the night-day, light-dark cycles that have ruled us since the dawn of humanity.

Our brain acts as timekeeper, keeping that clock in sync with the outside world. It rules our appetites, our sleep, our moods and much more.

But new research led by U-M Medical School scientists shows that the clock may be broken in the brains of people with depression — even at the level of the gene activity inside their brain cells.

It’s the first time this has ever been seen directly. Continue reading