Myeloproliferative neoplasms: A collection of rare blood cancers

Called MPNs for short, they may be caused by an abnormal cancer stem cell

myeloproliferative neoplasms

Each MPN is a different condition, but they are thought to be caused by an abnormal cancer stem cell that may have acquired genetic mutations that make it unable to produce blood cells normally


Myeloproliferative neoplasms, or MPNs, are a group of chronic blood cancers with the potential to rapidly progress to a more advanced stage or to an acute leukemia. Though our understanding of why these cancers occur is still evolving, we believe these MPNs can arise from a common cause: genetic alterations within the stem cell that change the way these blood cells grow and divide. Scientists are unraveling the mysteries of these rare cancers, bringing new hope for patients through research and specialized treatment.

mCancerPartner recently talked to Marie Huong Nguyen, M.D., a hematology/oncology MPN specialist at the U-M Comprehensive Cancer Center. Dr. Nguyen leads multiple clinical trials at U-M to develop new therapies in MPNs. Dr. Nguyen’s MPN and Systemic Mastocytosis Clinic focuses on the diagnosis, treatment and follow-up of patients with many different types of MPNs. Continue reading